Research reveals the pathogenesis of metabolic diseases March 20, 2017 Source: Bio Valley In a recent study, researchers from the Joan C. Edwards School of Medicine at Marshall University used a peptide called pNaKtide to inhibit the oxidative amplification of sodium-potassium pumps in cells. This effect can be used to alleviate experimental non-alcoholic fatty liver and diseases such as atherosclerosis. The results of this study were published in the most recent issue of "scientific reports". “We studied Dr. Zijian Xie from the Marshall Interdisciplinary Institute, Dr. Jiang Tian from Toledo University, and my co-developed peptide, pNaKtide, and performed it on two strains of mice fed a high-fat diet. "The trial," said Joseph I. Shapiro, senior author of the article, said: "Our results indicate that pNaKtide is very effective in relieving nonalcoholic fatty liver and atherosclerosis caused by high-fat diets. If this treatment can really be developed into a drug, it will greatly help the treatment of the above two diseases." The investigators noted that C57BL/6 mice developed insulin sensitivity, dyslipidemia, and weight gain after receiving an overdose diet, but these symptoms were evident after receiving the above peptides. Lighten. In addition, the content of high-density lipoprotein ("good" cholesterol) in mice is also increased, while the content of low-density lipoprotein ("bad" cholesterol) is decreased. In APOE knockout mice (which spontaneously develop atherosclerotic symptoms), the use of peptides also effectively reduces the severity of atherosclerosis. "In summary, our study suggests that the sodium-potassium-mediated oxidative amplification pathway plays an important role in the production of nonalcoholic fatty liver and atherosclerotic symptoms," said the first author of the article, also from medical researcher Komal Sodhi. Said: "Our findings will play a role in the treatment and prevention of these diseases." However, more trials are needed to validate before final application to clinical treatment. Tetanus Shot,Tetanus Vaccine,Hepatitis B Injection,Hep B Vaccine FOSHAN PHARMA CO., LTD. , https://www.fs-pharma.com